2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (253):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-161931
    Demethyl-RSL3-boc 2375354-07-5
    Demethyl-RSL3-boc is a ligand for target protein for pROTAC.
    Demethyl-RSL3-boc
  • HY-161960
    EP300/CBP ligand 2
    EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958).
    EP300/CBP ligand 2
  • HY-161807
    DENV ligand 1 1628758-48-4
    DENV ligand 1 is a ligand for DENV E protein. DENV ligand 1 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806).
    DENV ligand 1
  • HY-161711
    CBP/p300 ligand 5
    CBP/p300 ligand 5 is the target protein ligand of XYD129 (HY-161710). CBP/p300 ligand 5 can be used to study the acute myelogenous leukemia.
    CBP/p300 ligand 5
  • HY-159472
    SMARCA2/4-ligand-1 2411651-36-8
    2-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.
    SMARCA2/4-ligand-1
  • HY-10997R
    Ibrutinib (Standard) 936563-96-1
    Ibrutinib (Standard) is the analytical standard of Ibrutinib. This product is intended for research and analytical applications. Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM.
    Ibrutinib (Standard)
  • HY-168671
    pan-KRAS ligand 1 2886012-31-1
    pan-KRAS ligand 1 is a Ligand for Target Protein for PROTAC. pan-KRAS ligand 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669).
    pan-KRAS ligand 1
  • HY-161598
    DYRK2 ligand 1
    DYRK2 ligand 1 is a target protein ligand of PROTAC DYRK2 degrader 1 (HY-161597). DYRK2 ligand 1 can be used to study cancer.
    DYRK2 ligand 1
  • HY-168305
    EGFR ligand-11 2550394-08-4
    EGFR ligand-11 is a target protein ligand for EGFR and can be used to synthesize PROTAC MS154 (HY-141640).
    EGFR ligand-11
  • HY-170314
    EA-89
    EA-89 is a potent and selective BRD9 inhibitor with antitumor activity. EA-89 is a Ligand for Target Protein for PROTAC. EA-89 can be used to synthesize PROTAC QA-68 (HY-150797).
    EA-89
  • HY-118271
    GNF-8625 1196546-33-4
    GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.
    GNF-8625
  • HY-49319
    USP7-IN-14
    USP7-IN-14 is a Ligand for target protein for pROTAC.
    USP7-IN-14
  • HY-170599
    H117
    H117 is a PROTAC target protein ligand that can be used to synthesize PROTAC HP211206 (HY-170598). H117 has competitive binding and inhibition ability on SARS-CoV-2 main protease (Mpro) with an IC50 of 151.3 nM.
    H117
  • HY-143277
    HL-2 2766352-49-0
    HL-2 is a ligand of the target protein PI3K kinase of HL-8 (HY-143275), which can be used for PROTAC synthesis.
    HL-2
  • HY-168252
    BRM/BRG1 ligand 3 2933126-51-1
    BRM/BRG1 ligand 3 is a target protein ligand that can be used to synthesize PROTAC BRM/BRG1 degrader-3 (HY-168251).
    BRM/BRG1 ligand 3
  • HY-159542
    SMARCA2 ligand-6 2408394-89-6
    SMARCA2 ligand-6 is a ligand for target protein for pROTAC.
    SMARCA2 ligand-6
  • HY-W614725
    Apcin-A monohydrochloride 1683535-53-6
    Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V (HY-130257).
    Apcin-A monohydrochloride
  • HY-168288
    MEK ligand-2 212631-56-6
    MEK ligand-2, a MEK1 and MEK2 inhibitor, is a ligand for target protein for PROTAC of MS934 (HY-153863). MS934 is a VHL-recruiting MEK 1/2 PROTAC degrader.
    MEK ligand-2
  • HY-163526
    STAT3-IN-26 3033746-27-6
    STAT3-IN-26 is the ligand for the target protein STAT3 in PROTAC STAT3 degrader-3 (HY-163502), which can be used for the synthesis of PROTACs.
    STAT3-IN-26
  • HY-161808
    DENV ligand 2
    DENV ligand 2 is the ligand for DENV E protein.DENV ligand 2 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806). DENV ligand 2 is the active form of DENV ligand 1 (HY-161807).
    DENV ligand 2